Differential Alterations in Resting State Functional Connectivity Associated with Depressive Symptoms and Early Life Adversity

Depression and early life adversity (ELA) are associated with aberrant resting state functional connectivity (FC) of the default mode (DMN), salience (SN), central executive networks (CEN). However, specific differential associations depression ELA FC these remain unclear. Applying a dimensional approach, here we analyzed between major nodes DMN, SN, CEN severity depressive symptoms defined as childhood abuse neglect in sample 83 healthy depressed subjects. Depressive were linked to increased within SN decreased DMN CEN. Childhood was whereas DMN. Our study thus provides evidence for contributes clarification previously contradictory findings. Specific abnormalities may underlie cognitive emotional impairments. Future research should link clinical resulting from patterns thereby characterizing subtypes neurobiological signatures.